Important Safety Information
Please review the safety information below for each treatment offered by Pepton Health. This information does not replace the advice of your healthcare provider.
General Information
Pepton Health connects patients with licensed healthcare providers who may prescribe compounded medications through state-licensed pharmacies. All treatments require an online consultation with a licensed provider.
Compounded medications are customized preparations made by licensed pharmacies based on a provider's prescription. They are not FDA-approved for safety, efficacy, or manufacturing quality. The FDA does not verify the safety or effectiveness of compounded drugs.
The information on this page is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a medical emergency, call 911 or go to your nearest emergency room.
Compounded Semaglutide
What is compounded semaglutide?
Compounded semaglutide is a medication prepared by a licensed compounding pharmacy that contains the same active ingredient found in certain FDA-approved GLP-1 receptor agonist medications. Compounded medications are not FDA-approved and are prescribed by licensed healthcare providers based on individual patient needs.
Important warnings
Semaglutide carries a boxed warning regarding thyroid C-cell tumors. In rodent studies, semaglutide caused thyroid C-cell tumors. It is unknown whether semaglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans. Semaglutide is contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Who should not use this medication?
Do not use compounded semaglutide if you have a personal or family history of medullary thyroid carcinoma (MTC) or MEN 2. Do not use if you are allergic to semaglutide or any ingredients in the formulation. Do not use if you are pregnant or planning to become pregnant. Discontinue use at least 2 months before a planned pregnancy.
Common side effects
The most common side effects include nausea, vomiting, diarrhea, stomach pain, constipation, headache, fatigue, and injection site reactions. These are usually mild to moderate and tend to decrease over time as the body adjusts.
Serious side effects
Seek immediate medical attention for: severe abdominal pain that does not go away (possible pancreatitis), vision changes, signs of kidney problems (decreased urination, swelling in legs/feet), signs of gallbladder problems (upper stomach pain, fever, jaundice), rapid heartbeat, or signs of a severe allergic reaction (swelling of face/throat, difficulty breathing, severe rash).
Drug interactions
Semaglutide may affect how other medications work, especially insulin and other diabetes medications. It may slow gastric emptying, which can affect absorption of oral medications. Inform your healthcare provider about all medications you take, including over-the-counter drugs and supplements.
Compounded Tirzepatide
What is compounded tirzepatide?
Compounded tirzepatide is a medication prepared by a licensed compounding pharmacy that contains the same active ingredient found in certain FDA-approved GLP-1/GIP dual receptor agonist medications. Compounded medications are not FDA-approved and are prescribed by licensed healthcare providers based on individual patient needs.
Important warnings
Tirzepatide carries a boxed warning regarding thyroid C-cell tumors. In rodent studies, tirzepatide caused thyroid C-cell tumors. It is unknown whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans. Tirzepatide is contraindicated in patients with a personal or family history of MTC or MEN 2.
Who should not use this medication?
Do not use compounded tirzepatide if you have a personal or family history of medullary thyroid carcinoma (MTC) or MEN 2. Do not use if you are allergic to tirzepatide or any ingredients. Do not use if you are pregnant or planning to become pregnant.
Common side effects
The most common side effects include nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion, stomach pain, and injection site reactions. These are typically dose-related and may decrease over time.
Serious side effects
Seek immediate medical attention for: severe abdominal pain (possible pancreatitis), vision changes, signs of kidney problems, signs of gallbladder problems, severe allergic reactions, or hypoglycemia when used with insulin or sulfonylureas.
Sermorelin
What is sermorelin?
Sermorelin is a compounded synthetic peptide analog of growth hormone-releasing hormone (GHRH). It stimulates the pituitary gland to produce and release growth hormone naturally. Available as both injectable and oral dissolving tablet (ODT) formulations. Compounded sermorelin is not FDA-approved.
Who should not use sermorelin?
Do not use sermorelin if you have a known allergy to sermorelin or any of its components. Do not use if you are pregnant or breastfeeding. Do not use if you have active cancer or a history of cancer that may be stimulated by growth hormone. Use with caution if you have hypothyroidism, as this may interfere with sermorelin's effects.
Common side effects
For injections: injection site reactions (pain, swelling, redness), headache, flushing, dizziness, and nausea. For ODT tablets: headache, flushing, dizziness, nausea, and changes in taste. These are typically mild and transient.
Serious side effects
Serious side effects are rare but may include severe allergic reactions, changes in blood pressure, increased intracranial pressure, carpal tunnel syndrome, edema (fluid retention), and insulin resistance. Long-term use should be monitored by your healthcare provider.
Drug interactions
Sermorelin can interact with glucocorticoids (such as prednisone), thyroid hormones, insulin, and other medications that affect growth hormone levels. Always inform your healthcare provider of all medications you are taking.
NAD+
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring coenzyme found in every cell. It plays essential roles in energy metabolism, DNA repair, and cellular signaling. Compounded NAD+ is available as injectable and nasal spray formulations. Compounded NAD+ is not FDA-approved.
Who should not use NAD+?
NAD+ may not be appropriate for individuals who are pregnant or breastfeeding, have active cancer, or have a known allergy to any component of the formulation. Your healthcare provider will review your health history to determine if NAD+ therapy is appropriate.
Common side effects
For injections: injection site discomfort, nausea, flushing, lightheadedness, or headache. For nasal spray: nasal irritation, nausea, flushing, or headache. These are generally short-lived and resolve on their own.
Serious side effects
Serious adverse effects are rare. Seek immediate medical attention for: signs of a severe allergic reaction (difficulty breathing, swelling of face or throat, severe rash), chest pain, rapid or irregular heartbeat, or any symptoms that concern you.
Drug interactions
NAD+ may interact with certain medications. Always inform your healthcare provider of all medications and supplements you are currently taking before beginning NAD+ therapy.
Sildenafil
What is sildenafil?
Sildenafil is a PDE5 inhibitor used to treat erectile dysfunction by increasing blood flow during sexual stimulation. Compounded sildenafil is prepared by licensed compounding pharmacies and prescribed by licensed healthcare providers.
Who should not use sildenafil?
Do not use sildenafil if you take nitrates for chest pain or heart problems, including nitroglycerin — the combination can cause a dangerous drop in blood pressure. Do not use if you are allergic to sildenafil. Do not use if advised to avoid sexual activity due to heart problems.
Common side effects
Common side effects include headache, flushing, upset stomach, abnormal vision (color changes, blurred vision, light sensitivity), stuffy or runny nose, back pain, muscle pain, nausea, and dizziness.
Serious side effects
Seek immediate medical attention for: an erection lasting more than 4 hours (priapism), sudden vision loss in one or both eyes, sudden hearing decrease or loss, chest pain or irregular heartbeat during sexual activity, or signs of a severe allergic reaction.
Drug interactions
Do not take with nitrates, guanylate cyclase stimulators (riociguat), or other PDE5 inhibitors. Use caution with alpha-blockers, certain antifungals, HIV protease inhibitors, and some antibiotics. Always inform your provider of all medications.
Tadalafil
What is tadalafil?
Tadalafil is a PDE5 inhibitor used to treat erectile dysfunction with a longer duration of action than sildenafil. Compounded tadalafil is prepared by licensed compounding pharmacies and prescribed by licensed healthcare providers.
Who should not use tadalafil?
Do not use if you take nitrates for chest pain or heart problems. Do not use if allergic to tadalafil or any ingredients. Do not use if advised to avoid sexual activity due to heart problems. Use with caution if you have liver or kidney problems.
Common side effects
Common side effects include headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. Muscle aches and back pain usually occur 12–24 hours after taking tadalafil and typically resolve within 48 hours.
Serious side effects
Seek immediate medical attention for: an erection lasting more than 4 hours, sudden vision loss, sudden hearing decrease or loss, or chest pain during sexual activity.
This page was last updated on April 30, 2026. Pepton Health reserves the right to update this information at any time.
If you have questions about any of our treatments, please contact us at support@peptonhealth.com or speak with your assigned healthcare provider through your Pepton account.